| 摘要 |
<p>The present invention relates to a method useful for inhibiting viral helicases, and in particular, the hepatitis C virus NS3 helicase. The method employs compositions having formula (I) where R?1, R2, R3, R4¿, X and T are as described herein. Preferred compounds are those where R3 is an electron withdrawing group such as halo, CN or CO¿2R?1. More preferred are those compounds where R3 is an electron withdrawing group and R2 is OH. Most preferred are those compounds where R?2 and R3¿ are as just described and X is S. In particular, the compositions and methods of this invention are useful in treating diseases caused by hepatitis C virus, bovine viral diarrhea virus or vaccinia virus.</p> |
