发明名称 |
METHODS FOR IDENTIFYING CELLULAR RESPONSES ATTRIBUTABLE TO SIGNALING MOLECULE INHIBITION AND INHIBITORS THEREOF |
摘要 |
The present invention provides a method for the identification of a pattern of changes in cellular responses induced by the selective inhibition of a signaling molecule, by determining the specific effects of a selective inhibitor on a mutant form of a signaling molecule on cellular responses. The pattern of alterations in cellular responses resulting from the inhibition by a selective mutant inhibitor of the mutant signaling molecule are characteristic of the cellular response alterations that a specific inhibitor of the wild-type signaling molecule will produce. After determining the pattern of cellular responses of the mutant cells with the mutant molecule, compounds may be identified capable of inhibiting the wild-type molecule by producing a pattern of cellular responses in wild-type cells matching or having similarity to that of the inhibition of the mutant molecule.
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申请公布号 |
WO0107659(A2) |
申请公布日期 |
2001.02.01 |
申请号 |
WO2000US19912 |
申请日期 |
2000.07.21 |
申请人 |
PRINCETON UNIVERSITY;SHOKAT, KEVAN, M.;BISHOP, ANTHONY |
发明人 |
SHOKAT, KEVAN, M.;BISHOP, ANTHONY |
分类号 |
G01N33/53;C07D487/04;C12Q1/02;C12Q1/48;G01N37/00;(IPC1-7):C12Q1/68 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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