摘要 |
<p>A process for the resolution of enantiomeric mixtures of a chiral carboxylic acid, comprising an esterification reaction of said carboxylic acid in an organic solvent, in the presence of a stereoselective hydrolase, characterized in that an orthoester of the formula: R?1-C(OR2)¿3, in which R1 is selected from H and C¿1?-C4alkyl and R?2 is C¿1-C8alkyl or -CH2-C6-10aryl, is used as the esterification reactive.</p> |