发明名称 |
PROCESS FOR THE MANUFACTURE OF (SUB)MICRON SIZED PARTICLES BY DISSOLVING IN COMPRESSED GAS AND SURFACTANTS |
摘要 |
<p>The present invention relates to a process for manufacturing a pulverous preparation of a submicron-sized biologically active compound comprising the steps of dissolving a biologically active compound under elevated pressure in a compressed gas, liquid or supercritical fluid containing a surface modifier; and rapidly expanding the compressed solution thereby precipitating the dissolved compound. An alternative process comprises dissolving the biologically active compound in compressed dimethylether, which may optionally contain a surface modifier; and spraying the compressed solution into an antisolvent phase, optionally containing a surface modifier, under vacuum, atmospheric pressure or elevated pressure. An optional third step involves converting the antisolvent phase into a pulverous preparation using conventional powder processing.</p> |
申请公布号 |
EP1071402(A1) |
申请公布日期 |
2001.01.31 |
申请号 |
EP19990919195 |
申请日期 |
1999.04.06 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
BAUSCH, ALEXANDER;HIDBER, PIRMIN |
分类号 |
A61K9/14;A61K9/16;A61K31/337;A61K31/4725;A61K31/5375;A61K31/5513;A61K31/635;A61K31/7048;B01F3/00;B01F3/12;B01J2/00;B01J2/04;B01J3/00;B01J13/00;B01J13/02;B29B9/10;C08J3/12;(IPC1-7):A61K9/14;A61K31/015 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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