ALHPA-HYDROXY, -AMINO, AND -HALO DERIVATIVES OF BETA-SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS

摘要

The present invention provides a compound of formula or pharmaceutically acceptable salts thereof, wherein R1 is C4-12 alkyl, C4-12 alkenyl. C4-12 alkynyl, -(CH2)h-C3-8 cycloalkyl, substituted and unsubstituted -(CH2)h-aryl, substituted and unsubstituted -(CH2)h-het, R2 is substituted and unsubstituted C1-12 alkyl, substituted and unsubstituted C2-12 alkenyl, substituted and unsubstituted C2-12 alkynyl, substituted and unsubstituted-(CH2)h-C3-8 cycloalkyl, substituted and unsubstituted -(CH2)h-C3-8 cycloalkenyl. substituted and unsubstituted -(CH2)h-aryl, substituted and unsubstituted -(CH2)h-heterocyclic ring, substituted and unsubstituted -(CH2)i-X-R4 (X is -O-, -S(=O)j-, -NR7-, -S(-O)2NR8- or -C(-O-), and -(CH2)jCHR5R6. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation. 10 claims