| 摘要 |
<p>A process for preparing a compound of formula or a tautomeric form thereof or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein A1 represents a substituted or unsubstituted aromatic heterocyclic group; R1 represents a hydrogen atom, an alkyl group, an aralkyl group, wherein the aryl moiety may be substituted or unsubstituted, or a substituted or unsubstituted aryl group; A2 represents a benzene ring having in total up to five substituents; and n represents an integer in the range of from2 to 6, which process comprises catalytically reducing a compound of formula (II) wherein A1, R1, A2 and n are as defined in formula (I), characterized in that the reduction reaction is carried out using a hydrogen pressure above 20 psi(138kN/m2); and thereafter if required forming a pharmaceutically acceptable salt and/or pharmaceutically acceptable solvate of the compound of formula (I). 10 claims</p> |
