1,2,4-TRIAZOLO[4,3-B]PYRIDO[3,2-D]PYRIDAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

Heterocyclic compounds of formula (I), wherein R1 represents a hydrogen atom or a -(CH2)m-Y group, wherein m is an integer from 0 to 4 and Y represents an akyl, haloalkyl, alkoxy, C3-C7 cycloalkyl, norbornyl; or phenylalkenyl group, or an aromatic group which aromatic group Y may optionally be substituted by one or more halogen atoms; R2 represents an aromatic group which aromatic group may optionally be substituted by one or more halogen atoms or alkyl, alkoxy,C3-C6 cycloalkoxy, methylenedioxy, nitro, dialkylamino or trifluoromethyl groups; and R3 represents a hydrogen or halogen atom or an alkyl group, and pharmaceutically acceptable salts thereof, processes for preparing the same. The compounds are phosphodiesterase 4 inhibitors. 12 claims