| 发明名称 |
5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS |
| 摘要 |
The invention relates to novel 5,6-dihydropyrone derivatives and related structures of formula wherein the substitutes are of the given in the description values. The compounds inhibit the HIV aspartyl protease blocking HIV infection. The 5,6-dihydropyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized 5,6-dihydropyrones and of related structures. 31 claims
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| 申请公布号 |
BG63012(B1) |
申请公布日期 |
2001.01.31 |
| 申请号 |
BG19960100563 |
申请日期 |
1996.05.03 |
| 申请人 |
PARKE DAVIS & COMPANY |
发明人 |
ELLSWORTH, EDMUND L.;LUNNEY, ELIZABETH;TAIT, BRADLEY D. |
| 分类号 |
C07D335/02;A61K31/35;A61K31/351;A61K31/352;A61K31/365;A61K31/366;A61K31/38;A61K31/382;A61K31/44;A61K31/443;A61P31/04;A61P31/12;A61P31/18;C07C321/26;C07C323/20;C07C323/22;C07C381/04;C07D211/84;C07D211/86;C07D309/32;C07D309/38;C07D311/96;C07D405/04;C07D405/06;C07D405/12;C07D407/06;C07D407/12;(IPC1-7):C07D309/32 |
主分类号 |
C07D335/02 |
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