DORSAL TISSUE AFFECTING FACTOR AND COMPOSITIONS.

摘要

A novel and soluble polypeptide that is highly conserved among vertebrates has been discovered, which is designated "noggin." The properties of noggin include dorsal growth inducing activity. Noggin and activin act synergistically to produce dorsal mesoderm. Noggin's cDNA has been cloned. Several expression systems have been successfully used to express biologically active noggin. Amino acid sequences representing completely conserved portions as between frog noggin and mouse noggin are: QMWLWSQTFCPVLY (SEQ ID NO:3); RFWPRYVKVGSC (SEQ ID NO:4); SKRSCSVPEGMVCK (SEQ ID NO:5); LRWRCQRR (SEQ ID NO:6); and, ISECKCSC (SEQ ID NO:7).