发明名称 |
THIENYLAZOLYLALCOXYETHANAMINES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS |
摘要 |
<p>The thienylazolylalkoxyethanamines (I) where R1 is a hydrogen atom, a halogen atom or a lower alkyl radical; R2, R3 and R4 represent, independently, a hydrogen atom or a lower alkyl radical; and Az represents a five-member nitrogenated hetercyclic aromatic group, N-methyl-substituted, that contains from one to three nitrogen atoms. They have analgesic activity in mammals, including humans. The compounds (I) can be obtained, for example, by reaction of a derivative of hydroxy-thienylazol (IV) with a derivative of a suitable N-(ethyl)amine. The compounds (IV) are useful intermediates in the synthesis of the compounds (I). The compounds (I) have an application in human and/or veterinary medicine.</p> |
申请公布号 |
EP1072266(A1) |
申请公布日期 |
2001.01.31 |
申请号 |
EP19990913321 |
申请日期 |
1999.04.15 |
申请人 |
LABORATORIOS DEL DR. ESTEVE, S.A. |
发明人 |
MERCE-VIDAL, RAMON;ANDALUZ-MATARO, BLAS;FRIGOLA-CONSTANSA, JORDI |
分类号 |
A61K31/381;A61K31/401;A61K31/4155;A61P25/04;A61P29/00;A61P43/00;C07D231/00;C07D231/12;C07D333/00;C07D333/16;C07D409/04;C07D409/06;(IPC1-7):A61K31/38 |
主分类号 |
A61K31/381 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|