| 摘要 |
MyoD1 expression is found at early stages of embryonic myogenesis and in rhabdomyosarcoma, the most common soft-tissue cancer in children. Hypomethylation of a CpG island in the 5' upstream region of the human MyoD1 gene occurs in a majority of alveolar rhabdomyosarcomas, and may be responsible for higher levels of the MyoD1 expression in this tumor type. The methylation status of the upstream CpG island may play a key role in regulation of the MyoD1 expression not only in alveolar rhabdomyosarcoma, but also during normal development. This invention provides for the assessment of the methylation status of the MyoD1 upstream CpG sites, which may have valuable implications for differential diagnosis of pediatric cancers and may results in potential therapeutic applications.
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