Novel physiologically active substance, process for producing the same and use thereof

摘要

A urotensin II-like peptide originating in rat or mouse which is an SENR ligand or its salt; a nucleic acid encoding this SENR ligand; a method/kit for screening a compound capable of altering the binding properties of the SENR ligand to SENR, etc. DNA encoding the above-described polypeptide or the polypeptide is usable in: (1) searching the physiological effects of the above polypeptide; (2) constructing synthetic oligonucleotide probes or PCR primers; (3) acquiring DNA encoding an SENR ligand or a precursor protein; (4) developing a receptor-binding assay system and screening candidate compounds for drugs by using a recombinant receptor protein expression system; (5) acquiring an antibody and an antiserum; (6) developing diagnostics with the use of the DNA, RNA, antibody or antiserum; (7) developing drugs such as central nervous function controlling agents, circulatory function controlling agents and heart function controlling agents; (8) gene therapy; and the like.