| 摘要 |
The present invention discloses compounds of the formulawherein the dotted bonds are optional extra bonds allowing any tautomeric isomers compatible with substituents X and R3;R3 is non-existing, hydrogen, or alkyl;X is O, S, imino, alkoxy, alkylthio, or amino;R1 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, acyl, acylalkyl, alkoxyalkyl, dialkoxyalkyl, or phenylalkyl which may be substituted with alkyl, halogen, amino, nitro or cyano; andR4, R5, R6 and R7 independently of each other are hydrogen; halogen; amino; nitro;CN; CF3; COOH; COO-alkyl; alkyl; acyl; alkoxy; -(CH2)n,-OH wherein n is 0, 1, 2, or 3; -(CH2)m-O-alkyl wherein m is 0, 1,2, or 3; -(CH2)p-O-acyl wherein p is 0, 1,2, or 3;or a pharmaceutically acceptable addition salt thereof. The compounds are useful as pharmaceuticals, for example, in the treatment of traumatic lesions of peripheral nerves, the medulla, and/or the spinal cord, cerebral ischaemic neuronal damage, neuropathy and especially peripheral neuropathy, dementia, Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, or any other neurodegenerative disease.
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