发明名称 |
2-cyclopenten-1-one as an inducer of HSP70 |
摘要 |
The invention relates to 2-cyclopenten-1-one as an inducer of the heat shock protein HSP70 by activating the heat shock transcription factor HSF, and selectively inducing the transcription and translation of HSP70 in human cells. In particular, since a cytoprotective role of HSP70 during viral infection was previously shown, the invention refers to 2-cyclopenten-1-one and its pharmaceutically acceptable derivatives as inducers of HSP70 with antiviral activity. Treatment with 2-cyclopenten-1-one and its pharmaceutically acceptable derivatives causes a dose-dependent reduction of infectious virus yield during infection with vesicular stomatitis virus. The block of virus replication is due to inhibition of viral protein synthesis, associated with HSP70 synthesis.
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申请公布号 |
US6180681(B1) |
申请公布日期 |
2001.01.30 |
申请号 |
US19980202553 |
申请日期 |
1998.12.16 |
申请人 |
CONSIGLIO NAZIONALE DELLE RICERCHE |
发明人 |
AMICI CARLA;ELIA GIULIANO;GARACI ENRICO;ROSSI ANTONIO;SANTORO MARIA GABRIELLA |
分类号 |
A61P31/12;A61K31/122;A61P31/22;A61P43/00;(IPC1-7):A61K31/12;A61K31/015 |
主分类号 |
A61P31/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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