| 摘要 |
Preparation of pellets containing more than 50 wt.% of a drug (I) comprises aqueous granulation of a (I)-containing mixture, extrusion, rounding and drying. The starting mixture contains (i) at least 50 wt.% (I), (ii) upto 50 wt.% microcrystalline cellulose and low-substituted hydroxypropyl cellulose in weight ratio 4-6:66-4 and (iii) water giving good plasticity for extrusion and spheronization. Preparation of pellets containing more than 50 wt.% of a drug (I) of water-solubility more than 0.5 g/ml by aqueous granulation of a (I)-containing mixture, extrusion, rounding and drying the moist granulate. The starting mixture contains: (i) at least 50 wt. % (I); (ii) upto 50 wt.% of a combination of microcrystalline cellulose and low-substituted hydroxypropyl cellulose (both of average particle size 10-25 mu m) in weight ratio of 4-6:6-4 and (iii) only sufficient water to provide good plasticity for extrusion and spheronization. |
