BENZO(5,6)CYCLOHEPTA(1,2B)PYRIDINE DERIVATIVES USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

Novel compounds of formula (1.0) or a pharmaceutically acceptable salt or solvate thereof, wherein: a represents N or NO<->; R<1> and R<3> are the same or different and each represents halo; R<2> and R<4> are the same or different and each is selected from H and halo, provided that at least one of R<2> and R<4> is H; T is a substituent selected from SO2 R or (A); Z is O or S; n is zero or an integer from 1 to 6; R is alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, heterocycloalkyl, or N(R<5>)2; R<5> is H, alkyl, aryl, heteroaryl or cycloalkyl. Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.