| 摘要 |
molecular biology, virology. SUBSTANCE: invention relates to recombinant adenoviral vectors of expression exhibiting the partial or complete deletion of adenovirus DNA fragment that encodes the protein IX and containing gene encoding the foreign protein or its functional fragment or mutant form. Invention proposes a pharmaceutical composition including recombinant adenoviral expression vector which has insertion of exogenous DNA with gene encoding the foreign protein and adenoviral DNA with deletion from initial position 357 to 360 and terminal position from 4020 to 4050. Indicated pharmaceutical composition can be used in genetic therapy, for transformation of hyperproliferated cells in mammals, cancer therapy, inhibition of tumor proliferation in animals, decrease of tumor cells proliferation. EFFECT: recombinant vector indicated above, valuable biological and medicinal properties. 20 cl, 40 dwg, 2 tbl, 3 ex |
