| 摘要 |
medicine. SUBSTANCE: described are new compounds of formula I or II: AG-(CH2)n-CO2R1,AG-CH(R2)-CO3R1 wherein AG is (a) N-aminoguanidine, (b) N,N'-diaminoguanidine or (c) N,N',N''-triaminoguanidine, and n is integer of 1 to 5; R1 is (a) hydrogen, (b) phenyl, (c) C1-C5 alkyl or (d) C1-C3 alkylphenyl and R2 is (a) phenyl, (b) C1-C10 alkyl or (c) C1-C5 alkylphenyl under the following conditions (a) in formula I wherein n is 2 or 3, R1 is not hydrogen; (b) in formula I when n is 1, R1 is not methyl; (c) in formula II when R2 is ethyl or phenyl, R is not hydrogen; (d) compound is not N-aminogauanyl glycine or N-aminoguanyl-DC-phenylalanine. Properties of new compounds make then useful for treating insulin-independent diabetes. EFFECT: improved properties of the title compounds. 3 cl, 4 dwg, 15 ex, 9 tbl
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