| 摘要 |
pharmaceutical chemistry. SUBSTANCE: invention provides novel benzofuran carboxamides depicted by general formula I: (I), in which Z is CO group; R1 is alkoxy group optionally substituted by one or several halogen atoms; R2 and R3, identical or different, are hydrogen, groups R6,OR10,COR6,C(=NOR6)R6, alkyl-C(=NOR6)R6, C(=NOR6)R6,NR8R9, CN, CF3, COOH, and COOR10; R4 is hydrogen or alkyl; R5 aryl, heteroaryl, and heterocyclic radical, alkyl/aryl/heteroaryl/heterocyclic moieties in R4 and/or R5 being optionally substituted by one or several substituents R13; R6 is group R10 optionally substituted in any position by groups R16; R7 is hydrogen or alkyl; R8 hydrogen, heteroarylalkyl, heterocycloalkyl, or alkoxycarbonyl; R9 hydrogen, heteroarylalkyl, or alkyl; R10 alkyl, cycloalkyl, aryl, heteroaryl, heterocyclic radical, arylalkyl, heteroarylalkyl, or heterocycloalkyl; R11 hydrogen or alkyl; R12 hydrogen; R13 alkyl optionally substituted by hydrogen, alkoxy optionally substituted by halogen, heterocyclic radical, hydroxy, COOR7, halogen, CN, or S(O)nR10; R14 is hydroxyl, carbonyl oxygen, OR10, NR8R9, CN, COOH, CO2R10, or CONR11R12; and n is equal to 0; or their pharmaceutically acceptable salts. Pharmaceutical composition is also described. Compounds I can be used as phosphodiesterase inhibitors and in treatment of pathologic conditions caused by proteins mediating cellular activity. EFFECT: extended assortment of biologically-active compounds. 20 cl, 2 tbl, 52 ex |
