| 摘要 |
The compounds of formula 1 may be used in the treatment and prevention of a pestivirus infection in a mammalian host. In formula 1: A represents a substituent selected from the group consisting of: (a) NR1R2 wherein R1 and R2 are radicals independently selected from the group consisting of H, straight or branched chain alkyl groups (C1-C6), substituted or unsubstituted aryl groups, substituted or unsubstituted aralkyl groups in which the alkyl group is C1-C6, alkoxy groups (C1-C6), acyl groups (C1-C7), substituted or unsubstituted carbalkoxy groups (C1-C8 alkoxy), or R1 and R2, together with the nitrogen atom to which they are attached, represent a substituted or unsubstituted heterocyclic ring selected from the group consisting of benzopyridazine, indole, benzotriazole, hexamethyleneimine, imidazole, isoxazole, morpholine, phthalimide, piperidine, piperazine and pyrrolidine; (b) a substituted or unsubstituted heterocyclic group selected from the group consisting of pyridine, benzimidazole, benzodioxane, benzofurazan, indole, benzothiophene, coumarin, furan, hexamethyleneimine, isoxazole, oxadiazole, piperazine, piperidine, pyridine, pyrimidine, pyrrolidine, quinoline, quinuclidene, tetrahydropyran and thiazole; (c) a substituted or unsubstituted phenyl group; and (d) OR3, wherein R3 represents a radical selected from the group consisting of H, a straight or branched chain alkyl (C -C6) group, a substituted or unsubstituted phenyl group, a substituted or unsubstituted phenylalkyl group wherein the alkyl group is C1 -C6, or a substituted or unsubstituted tetrahydropyran; Q represents a linking moiety selected from the group consisting of -[(A')n -(CO)]p-, -S-, (SO)-, -(SO2)- or a valence bond, A' being -NRa- or -O- and Ra being H or alkyl (C1-C6); Rb, Rc and Rd independently represent H, alkyl (C1-C4), substituted or unsubstituted phenyl or COOR, R being hydrogen or alkyl (C1-C6); said phenyl, aryl, aralkyl, carbalkoxy and heterocyclic substituents and the W, X, Y and Z substituents are selected from the group consisting of H, alkyl (C1-C6), substituted or unsubstituted aryl (C6-C15), substituted or unsubstituted aralkyl (C7 -C15), halogen, CF3, CN, O-alkyl (C1-C6), acyloxy (C1 -C6 acyl), S-alkyl (C1-C6), SO-alkyl (C1 -C6), SO2 -alkyl (C1 -C6), NH2SO2, NO2, NH2, NHR', NR'R", alkyl COOR', COOR', alkyl CONR'R", CONR'R" or a group depicted above, wherein R' and R" are independently selected from the group consisting of hydrogen or alkyl (C1-C6); m is an integer from 0 to 6; n and p independently represent 0 or 1; and q and r are independently integers from 0 to 4.
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