Composition containing vertebrate cells, microspheres and soluble collagen which gels to form collagen fibrils

摘要

A composition comprising: a).a plurality of cultured vertebrate cells genetically engineered to express a polypeptide; b).a plurality of microspheres and c).a solution of soluble collagen wherein there is sufficient collagen in the composition to allow the composition to gel at a pH above 5. The soluble collagen in the composition forms a gel of insoluble collagen fibrils in which the cells and the microspheres are embedded.