| 摘要 |
PURPOSE: A production is provided to obtain, through an industrially applicable method, the subject compound useful as an intermediate for producing pharmacologically active compounds, e.g. an HMG-CoA reductase inhibitor, by reacting a specific methanol compound with chlorodiphenylphosphine. CONSTITUTION: This compound of formula ll is obtained by reacting (A)£4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl|meth anol of formula I. with (B) chlorodiphenylphosphine. The above reaction is carried out pref., for example, by directly reacting the component A with the component B, and thereafter, with a base (pref. an alkali metal hydroxide such as sodium hydroxide). It is desirable that this direct reaction of the component A with the component B is carried out at-20 to 130 °C, using a phase-transfer catalyst such as tetrabutylammonium chloride.
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