发明名称 4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one derivatives and their use as dopamine autoreceptor (D2) agonists
摘要 A compound having the formula I wherein: R1 is hydrogen or alkyl; R2 is hydrogen, alkyl, cyclohexylmethyl or -(CH2)mAr; Ar is phenyl, naphthyl, thienyl, furanyl or pyridinyl, each optionally substituted by one or two substituents selected independently from alkyl, halogen, alkoxy and trifluoromethyl; or NRlR2 is 1, 2, 3, 4-tetrahydroquinolin-1-yl or 1, 2, 3, 4-tetrahydroisoquinolin-2-yl; m is 1-5; n is 1 or 2; R3 is hydrogen or alkyl; Y is hydrogen, halogen, alkyl or alkoxy. These compounds are useful in treating diseases that respond to a dopamine D2 agonist.
申请公布号 NZ337271(A) 申请公布日期 2001.01.26
申请号 NZ19980337271 申请日期 1998.01.13
申请人 AMERICAN HOME PRODUCTS CORPORATION 发明人 MEWSHAW, RICHARD ERIC;NELSON, JAMES ALBERT;SHAH, URESH SHANTILAL
分类号 A61K31/4184;A61K31/4725;A61P25/16;A61P25/18;A61P25/30;C07D235/26;C07D401/12;C07D409/12;(IPC1-7):A61K31/47;A61K31/415 主分类号 A61K31/4184
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