| 发明名称 |
Purified human alpha-galactosidase A and therapeutic use |
| 摘要 |
<p>Glycosylated human alpha-gal A may be obtained from a culture of immortalized human cells transfected with an alpha-gal A encoding DNA molecule linked to a heterologous signal peptide, which permits overexpression of the alpha-galA polypeptide in the cells. The purified glycosylated human a-gal A may be used in a therapeutic method for treating a-galactosidase A deficiency, such as Fabry disease.</p> |
| 申请公布号 |
NZ334721(A) |
申请公布日期 |
2001.01.26 |
| 申请号 |
NZ19970334721 |
申请日期 |
1997.09.12 |
| 申请人 |
TRANSKARYOTIC THERAPIES, INC |
发明人 |
SELDEN, RICHARD F;BOROWSKI, MARIANNE;GILLESPIE, FRANCES P;KINOSHITA, CAROL M;TRECO, DOUGLAS A;WILLIAMS, MELANIE D |
| 分类号 |
C12N15/09;A61K35/12;A61K38/00;A61K38/46;A61K38/47;A61K47/42;A61K48/00;A61P9/00;A61P13/12;A61P35/00;A61P43/00;C07K14/61;C07K19/00;C12N5/10;C12N9/40;C12R1/91;(IPC1-7):C12N5/22;C12N15/62;C12N15/56 |
主分类号 |
C12N15/09 |
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