Anti-proliferative radiolabelled DNA oligonucleotide, preparation and use for controlling uncontrolled cell proliferation

摘要

An anti-proliferative substance for preventing uncontrolled cellular proliferation such as cancer or malignant tumors. It comprises a radiolabeled DNA carrier comprising a DNA sequence selected from the group consisting of: CAC GTT GA*G GGG CAT ATG CCC C*TC AAC GTG GCC CGA* GAA CAT CAT CCT CGC* AGT TTC CAT (* indicates the position of the radioisotope) A radioisotope is located internally within the DNA sequence at any position between nucleotides 4 and 12. The radiolabeled DNA carrier penetrates a cell membrane and is retained intracellularly for a time sufficient for the radioisotope to effect an efficient dose therapy.