发明名称 |
NMDA (n-methyl-d-aspartate) antagonists which preferentially bind to the strychnine-insensitive glycine binding site on the NMDA receptor complex |
摘要 |
Excitatory amino acid antagonists of formula (1). These antagonists are useful as NMDA (N-methyl-D-aspartate) antagonists and preferentially bind to the strychnine-insensitive glycine binding site on the NMDA receptor complex. Also disclosed are pharmaceutical compositions containing these amino acid antagonists and the use of the composition to treat ischemic/hypoxic/hypoglycaemic damage to cerebral tissue and anxiety as well as being useful for producing an analgesic effect.
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申请公布号 |
NZ334343(A) |
申请公布日期 |
2001.01.26 |
申请号 |
NZ19970334343 |
申请日期 |
1997.08.18 |
申请人 |
HOECHST MARION ROUSSEL, INC |
发明人 |
HARRISON, BOYD L;GROSS, RAYMOND S;BARON, BRUCE M |
分类号 |
A61K31/404;A61P25/00;C07D209/42;(IPC1-7):A61K31/40 |
主分类号 |
A61K31/404 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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