OLIGONUCLEOTIDES FOR METABOTROPIC GLUTAMATE RECEPTOR TYPE 1 (MGLUR1

摘要

The present invention relates to antisense oligonucleotides for metabotropic glutamate receptor type 1 (mGluR1). There is provided oligonucleotides that hybridize to a mRNA encoding mGluR1 or a splice variant thereof. There is also provided a method for treating a patient having a disorder related to an elevated glutamate level, such as chronic pain, or to enhance an opioid effect or to reduce opioid dependence and/or tolerance, which comprises the administration of such an oligonucleotide. Specific pain treatment is thereby obtained.