| 摘要 |
<p>The present invention provides a system for the growth of C.tetani and production of Tetanus Toxin for use in formulating Tetanus Toxoid preparations. The system includes growth media that contain significantly reduced levels of meat or dairy by-products using non-animal based products to replace the animal-derived products. Preferred media are substantially free of animal-derived products. Preferred media substantially free of animal-derived products comprise soy as a source of amino acids. The present invention also provides methods for production of Tetanus Toxin by culturing C. tetani in media substantially free of animal-derived products and comprising hydrolyzed soy, glucose and iron.</p> |
