发明名称 |
Aldolase catalytic antibody |
摘要 |
Antibodies that catalyze the aldol reaction are generated by immunization with a reactive compound that covalently traps a Lysine (Lys) residue in the binding pocket of the antibody by formation of a stable vinylogous amide, i.e., a covalent antibody/hapten complex. The resultant catalytic antibodies employ a catalytic mechanism which mimics the catalytic mechanism employed by natural class I aldolase enzymes. |
申请公布号 |
AU729055(B2) |
申请公布日期 |
2001.01.25 |
申请号 |
AU19970012923 |
申请日期 |
1996.12.16 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
CARLOS F. BARBAS III;RICHARD A. LERNER;JUERGEN WAGNER |
分类号 |
C07C45/45;C07C231/12;C07C233/33;C07K16/44;C12N5/10;C12N5/18;C12N9/00;C12N9/88;C12N15/06;C12P7/26;C12P13/00;C12P21/08 |
主分类号 |
C07C45/45 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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