发明名称 |
Method for the preparation of citalopram |
摘要 |
Preparation of citalopram (I) or its salt comprises reacting a isobenzofuran compound (IV) with (i) a cyanide source in the presence of a palladium catalyst and a catalytic amount of copper I or zinc II ions; or (ii) with zinc cyanide in the presence of a palladium catalyst; and isolating (I). - Preparation of citalopram of formula (I) comprises reacting an isobenzofuran compound of formula (IV) with (i) a cyanide source in the presence of a palladium catalyst and a catalytic amount of copper I or zinc II ions; or (ii) with zinc cyanide in the presence of a palladium catalyst; and isolating (I). - R = halo or CF3(CF2)nSO2; - n = 0-8. - An INDEPENDENT CLAIM is also included for (IV; R = CF3(CF2)nSO2 or iodo). |
申请公布号 |
SE0100193(D0) |
申请公布日期 |
2001.01.24 |
申请号 |
SE20010000193 |
申请日期 |
2001.01.24 |
申请人 |
H LUNDBECK AS |
发明人 |
HANS *PETERSEN;MICHAEL HAROLD *ROCK;HENRIK *SVANE |
分类号 |
A61K31/343;A61P25/24;A61P29/00;C07B61/00;C07D307/81;C07D307/87;(IPC1-7):C07D/ |
主分类号 |
A61K31/343 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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