<p>A pharmaceutical composition for increasing bone mass and preventing loss of bone mass is provided, comprising a fluoride source and a mitogenic hydantoin in combination with a pharmaceutically acceptable carrier, in which the fluoride source provides a molar ratio of fluoride ion to hydantoin in the composition of from about 0.1:1 to about 100:1. The combination is administered to a vertebrate, typically in the form of an orally administratable tablet or capsule.</p>
申请公布号
EP0557498(B1)
申请公布日期
2001.01.24
申请号
EP19920919468
申请日期
1992.09.09
申请人
BAYLINK, DAVID JESTON, PROF. DR.;EWERS, ROLF, PROF. DR. DR.;KIRSCH, AXEL, DR.
发明人
BAYLINK, DAVID JESTON, PROF. DR.;EWERS, ROLF, PROF. DR. DR.;KIRSCH, AXEL, DR.