| 摘要 |
PROBLEM TO BE SOLVED: To obtain a derivative of 1,2-benzothiazolin-3-one having various bioactivities, producible in an industrially profitable method overcoming a defect of using toxic chlorine gas for preparation of a starting raw material. SOLUTION: This compound is expressed by formula I (R1 to R4 are each H or a substituent; Ar is an aromatic substituent), e.g. a compound expressed by formula II. The compound of formula I is obtained, for example, in a method, etc., reacting (A) a 1,2-benzisothiazoline-3-one compound of formula III having no substituent at the 2-position, and (B) a sulfenamide compound of the formula: Ar-S-NH2 having N-S bond which is relatively easy to cleave, in (C) a reaction solvent if necessary, preferably at 50-150 deg.C, more preferably at 80-120 deg.C, for 2-12 hours. Ethyl 2-sulfenamoylbenzoate, isopropyl 2-sulfenamoylbenzoate, ethyl 2-sulfenamoylpyridine-3-carboxylate, etc., are enumerated as the component B.
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