发明名称 |
Bacteriohopanetetrol and related compounds useful for modulation of lipoxygenase activity and anti-inflammatory applications |
摘要 |
The arachidonic acid-metabolizing hopanoid tetrahydroxybacteriohopane (THBH) was isolated from Zymomonas mobilis and was found to inhibit soybean 15-lipoxygenase, and thus lipoxin biosynthesis, with an IC50 of about 10 muM. The activities of two other arachidonic acid-metabolizing enzymes, human 5-lipoxygenase (involved in prostaglandin biosynthesis) and prostaglandin H synthase, were unaffected by THBH. Subsequent studies showed that THBH was effective as an anti-inflammatory agent in topical applications.
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申请公布号 |
US6177415(B1) |
申请公布日期 |
2001.01.23 |
申请号 |
US19970844631 |
申请日期 |
1997.04.21 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE |
发明人 |
MOREAU ROBERT A.;HICKS KEVIN B. |
分类号 |
A61K31/56;A61K31/58;(IPC1-7):A61K31/56 |
主分类号 |
A61K31/56 |
代理机构 |
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代理人 |
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地址 |
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