| 摘要 |
organic chemistry, pharmacy. SUBSTANCE: invention describes substituted amides of the formula (I) TNFalpha where TNFalpha means substituted phenyl; is alkyl, phenyl, pyridyl, heterocyclyl and others; R1 is ethylene, vinylene, branched alkylene and others; R2 means R3, -CX where X is O or S. Compounds of the formula (I) have capability to decrease the level of R4 and inhibit CH2-activated replication of retroviruses and therefore they can be used for control of cachexia, endotoxic shock and replication of retroviruses. Compounds of the formula (I) are synthesized by interaction of substituted amine with corresponding anhydride, phthalimide or aldehyde. EFFECT: improved method of synthesis, valuable antiviral properties. 21 cl, 13 ex
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