发明名称 |
DIM MUTANTS OF MYCOBACTERIA AND USES THEREOF |
摘要 |
Disclosed are novel recombinant mutant strains of mycobacteria that are deficient for the synthesis or transport of dimycoserosalphthiocerol ("DIM"). The present invention also provides a method of producing a recombinant mutant mycobacterium that is deficient for the synthesis or transport of DIM, comprising mutating a nucleic acid responsible for the synthesis or transport of dimycoserosalphthiocerol, including a nucleic acid comprising the promoter for the pps operon, fadD28 or mmpL7. The present invention also provides a vaccine comprising a DIM mutant mycobacterium of the present invention, as well as a method for the treatment or prevention of tuberculosis in a subject using the vaccine.
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申请公布号 |
WO0103731(A1) |
申请公布日期 |
2001.01.18 |
申请号 |
WO2000US40312 |
申请日期 |
2000.07.06 |
申请人 |
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY |
发明人 |
COX, JEFFREY, S.;JACOBS, WILLIAM, R., JR. |
分类号 |
A61P31/04;C07K14/35;C12N1/21;(IPC1-7):A61K39/02;A61K39/04;G01N33/53;G01N33/573;C12P21/06;C12N1/12;C12N1/20;C12N9/00 |
主分类号 |
A61P31/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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