| 摘要 |
<p>The cell line comprises a DNA construction which includes all or part of a promoter sequence of the cyclooxygenase-2 (cox-2) gene and a witness gene, operatively jointed to each other, so that said promoter sequence of the cox-2 gene directs the expression of said witness gene in response to an adequate stimulus. The assay method comprises contacting said cell line with the compound to be assayed and determining the existence of a signal which is indicative of the expression of the activity due to the witness gene. Said method is appropriate for searching cox-2 transcriptional induction selective inhibitors through appropriate stimuli.</p> |
