MONOESTER COMPOUND, PHARMACEUTICAL COMPOSITION IT CONTAINING, AND USE OF THIS COMPOUND

摘要

A compound of the general formula Nu-O-Fa wherein O is oxygen, Nu is a nucleoside analogue, Fa is an acyl group of a mono-unsaturated C18 or C20 omega-9 fatty acid, which fatty acid is esterified with a hydroxyl group in the 5'-position of the sugar moiety of the nucleoside analogue or with a terminal hydroxyl group on the non-cyclic group of the nucleoside analogue, and wherein Nu is represented by the formula B-S wherein S is either a mono-saccharide-derivative selected from: 1-beta-D-ribofuranose, 1-beta-D-arabinofuranose, 2-deoxy-1-beta-D-ribofuranose, 2,3-dideoxy-1-beta-D-ribofuranose, 2,3-didehydro-2,3-dideoxy-1-beta-D-ribofuranose, 2-deoxy-2-fluoro-1-beta-D-arabinofuranose, 2,2-dideoxy-3-azido-1-beta-D-ribofuranose or 4-hydroxymethyl-2-cyclopenten-1-yl, or selected from the group of 2-hydroxy-ethoxy-methyl, 4-hydroxy-3-(hydroxymethyl)-butyl, 2-hydroxy-1-(hydroxymethyl)-ethoxy-methyl, 2,3-dihydroxy-propoxy or 2,3-dihydroxy-propyl; and B is a heterocyclic ring system selected from the following formulas: wherein X = O, S, NH and R1 = NH2, CH3, CH3 O and A = NH, S, Se, CH2, O, or wherein X = NH, S, O and Y = H, OH, F, Cl, Br, I, NH2, CH2 CN, C.dbd.CH or wherein R4 = H, NH2, NHOH, NHCOCH3, NHCH3, NHNH2 and R5 = H, F, Cl, Br, I, CH3, CF3 and R6 = CH3, I, CH.dbd.CHBr, CH2 OH, CH2 NH2, C.dbd.CCH3 or wherein R2 = OH, SH, H, Cl and R3 = H, OH, Cl, SH, NH2.