摘要 |
<p>A vaccine contains at least one Drosophila cell-secreted, recombinantly-produced form of a truncated Flavivirus envelope glycoprotein, as an active ingredient, and an adjuvant, as a critical component of the vaccine. The adjuvant is an immunomodulating agent having an iscom-like structure and comprising within the iscom-like structure at least one lipid and at least one saponin, and a pharmaceutically acceptable vehicle. Such a vaccine protects a subject against infection by a Flavivirus .</p> |
申请人 |
HAWAII BIOTECHNOLOGY GROUP, INC.;IVY, JOHN;BIGNAMI, GARY;MCDONELL, MICHAEL;CLEMENTS, DAVID, E.;COLLER, BETH-ANN, G. |
发明人 |
IVY, JOHN;BIGNAMI, GARY;MCDONELL, MICHAEL;CLEMENTS, DAVID, E.;COLLER, BETH-ANN, G. |