| 摘要 |
<p>The invention relates to a method of predicting an increased risk of a patient having Alzheimer's disease (AD) or for a subject of developing AD comprising: a) assaying a DNA-containing biological sample for the allele of the APOE gene; b) assaying the plasmatic level of protein Lp(a) or glycoprotein Apo(a), wherein the presence of an ε4 allele of the APOE gene and an increased plasmatic level of [Lp(a)]/Apo(a) indicates an increased risk for the patient having Alzheimer's disease or developing AD. The invention further provides a therapy for preventing or treating AD consisting of decreasing the plasmatic level of Lp(a) or the interaction of Lp(a) with its receptor in a patient bearing at least one APOE ε4 allele.</p> |
