| 发明名称 |
PYRROLIDINCARBONYLAMINO CYCLIC DISULFIDES AS VCAM-VLA4 ANTAGONISTS |
| 摘要 |
Compounds of formula (I) are described which have activity as anti-inflammatory agents. Cyclic disulfide compounds are provided which inhibit of binding of cells to endothelium. Such compounds are useful for treating inflammatory diseases, such as asthma, whose symptoms and/or damage are related to the binding of cell adhesion molecules to integrin expressing cells.
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| 申请公布号 |
WO0063234(A3) |
申请公布日期 |
2001.01.18 |
| 申请号 |
WO2000EP03459 |
申请日期 |
2000.04.17 |
| 申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
CHEN, LI;FOTOUHI, NADER;JACKSON, DAVID, YOUNG;TILLEY, JEFFERSON, WRIGHT |
| 分类号 |
A61K38/00;A61P11/06;A61P29/00;C07C323/60;C07K5/02;(IPC1-7):C07K5/02;A61K38/04 |
主分类号 |
A61K38/00 |
| 代理机构 |
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