发明名称 |
MOLECULAR DETERMINANTS OF TROPISM AND VIRULENCE IN ENTEROVIRUSES |
摘要 |
Recombinant enteroviruses for use as vaccines or vectors, which are modified in tropism or virulence, are disclosed. Also disclosed are DNA constructs comprising enterovirus-derived molecular determinants of tropism or virulenc e for use in targeting genes of interest to specific cells or tissues. The recombinant enteroviruses and DNA constructs comprise molecular determinants of tropism and virulence localized in specific domains of the 5'NTR of the enteroviral genome.
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申请公布号 |
CA2379221(A1) |
申请公布日期 |
2001.01.18 |
申请号 |
CA20002379221 |
申请日期 |
2000.07.08 |
申请人 |
UNIVERSITY OF NEBRASKA BOARD OF REGENTS |
发明人 |
DUNN, JAMES J.;ROMERO, JOSE R.;BRADRICK, SHELTON S. |
分类号 |
C12N7/00;C12N7/04;C12N15/86;(IPC1-7):C12N7/04;C07H21/02 |
主分类号 |
C12N7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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