| 摘要 |
<p>The invention concerns the field of organic chemistry, and more precisely, that of therapeutic chemistry. More particularly, the invention concerns novel esters derived from nucleosides of general formula (I) wherein: A represents a divalent group selected among -(CH2)n-, -(CH2)n -NH-, -(CH2)n -O-; (a); (b); (c); (d); (e); n is an integer ranging between 1 and 12; Z represents an amino, hydroxyl or an alkyl group; and the nucleoside group is the radical of a hydroxylated nucleoside of general formula (1) wherein: R1 represents a radical selected among (2) and (3) wherein: R4 represents a methyl, trifluoromethyl or halovinyl; R2 represents a hydrogen or a hydroxyl; R3 represents a hydrogen, a hydroxyl or an azido; and the dotted line represents an optional carbon-carbon double bond. The invention is useful as an antiviral agent.</p> |
