发明名称 |
UNMARKED DELETION MUTANTS OF MYCOBACTERIA AND METHODS OF USING SAME |
摘要 |
Disclosed is a recombinant slow-growing mycobacterium comprising at least one mycobacterial gene containing an unmarked mutation, wherein an "unmarked mutation" is a mutated nucleotide sequence introduced into a mycobacterium where the introduced mutated nucleotide sequence does not contain a selectable marker, such as a gene conferring antibiotic resistance to the recombinant mycobacterium incorporating the mutated nucleotide sequence. Also disclosed is a method for preparing a recombinant slow-growing mycobacterium comprising at least one mycobacterial gene containing an unmarked mutation, as well as a vaccine comprising a recombinant slow-growing mycobacterium having at least one mycobacterial gene containing an unmarked mutation dispersed in a physiologically acceptable carrier. Further disclosed is a method of treating or preventing tuberculosis in a subject comprising administering the vaccine of the present invention in an amount effective to treat or prevent tuberculosis in the subject.
|
申请公布号 |
WO0103730(A1) |
申请公布日期 |
2001.01.18 |
申请号 |
WO2000US18453 |
申请日期 |
2000.07.06 |
申请人 |
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY |
发明人 |
JACOBS, WILLIAM, R., JR.;PAVELKA, MARTIN, S., JR. |
分类号 |
A61K39/00;A61P31/04;C12N1/21;C12N9/02;C12N15/74;(IPC1-7):A61K39/02;A61K39/04;C12N1/20;C12N15/09;C12Q1/68;G01N33/569 |
主分类号 |
A61K39/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|