发明名称 |
THERAPY, PREVENTION OF RECURRENCE, AND DIAGNOSIS OF COLORECTAL CANCER WITH RADIOPHARMACEUTICALS |
摘要 |
Methods and composition for therapy, prevention of recurrence, and diagnosis of colorectal cancer with radiopharmaceuticals. A prodrug is administered of a desired active cytotoxic pharmaceutical, specifically a radiopharmaceutical. The prodrug is converted to the active pharmaceutical at the desired site of the malignancy or potential malignancy. For example, glycoside derivative prodrugs of 5-[<125>]iodo-2'-deoxyuridine are converted to the desired active form in the lumen of the intestine by the glycosidases produced by intestinal bacterial flora.
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申请公布号 |
WO0103745(A2) |
申请公布日期 |
2001.01.18 |
申请号 |
WO2000US18656 |
申请日期 |
2000.07.07 |
申请人 |
BOARD OF REGENTS OF UNIVERSITY OF NEBRASKA;BARANOWSKA-KORTYLEWICZ, JANINA;KORTYLEWICZ, ZBIGNIEW, PAUL |
发明人 |
BARANOWSKA-KORTYLEWICZ, JANINA;KORTYLEWICZ, ZBIGNIEW, PAUL |
分类号 |
A61K41/00;A61K51/04;(IPC1-7):A61K51/04 |
主分类号 |
A61K41/00 |
代理机构 |
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