HUMAN NUCLEIC ACID SEQUENCES FROM PROSTATE TUMOUR TISSUE

摘要

Nucleic acid sequences (A) that are expressed at high level in prostatic tumor tissue and encode gene products or their fragments are new. (A) is: (a) one of 54 sequences (all reproduced), all fully defined in the specification; (b) allelic variants of 38 of these sequences; or (c) the complements of these 38 sequences. Independent claims are also included for the following: (1) bacterial or phage artificial chromosomes, or cosmid clones, containing functional genes and their chromosomal locations corresponding to (A), for use as gene transfer vehicles; (2) fragments of (A) large enough to hybridize to (A); (3) expression cassette (EC) comprising (A), or its fragments, plus at least one control or regulatory element; (4) DNA fragments containing a gene obtained using (A); (5) host cells containing (A) or its fragments as a heterologous component of the genome; (6) recombinant production of polypeptides (I), or their fragments, by culturing these cells; (7) antibodies (Ab) directed against (I) or its fragments; (8) 74 polypeptide partial sequences (I), all reproduced, and sequences at least 80 (especially 90) % homologous with them; (9) a pharmaceutical composition containing at least one (I); and (10) genomic genes, their promoters, enhancers, silencers, exon or intron structures, or slice variants, obtained using (A).