| 发明名称 |
INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE |
| 摘要 |
The present invention is directed to piperazine-2,3-dione compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras. |
| 申请公布号 |
EP0891350(A4) |
申请公布日期 |
2001.01.17 |
| 申请号 |
EP19970917667 |
申请日期 |
1997.03.27 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
DINSMORE, CHRISTOPHER, J.;WILLIAMS, THERESA, M. |
| 分类号 |
A61K31/00;A61K31/495;A61K31/496;A61P9/00;A61P13/00;A61P13/12;A61P27/00;A61P27/02;A61P31/00;A61P31/12;A61P35/00;A61P43/00;C07D401/06;C07D403/04;C07D403/06 |
主分类号 |
A61K31/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
