发明名称 |
Method of detecting a chromosomal rearrangement involving a breakpoint in the ALK or NPM gene |
摘要 |
The present invention is based on the identification and sequence determination of a novel gene, ALK, which is fused to the gene encoding nucleophosmin (NPM) in translocations present in t(2;5) lymphoma cells. Based on homologies to other proteins, the amino acid sequence of the polypeptide encoded by the ALK (Anaplastic Lymphoma Kinase) gene is a membrane-spanning protein tyrosine kinase (PTK)/receptor. Antibodies to the ALK PTK/receptor and methods utilizing such antibodies are described, as are methods of using the ALK gene to isolate ligands for the ALK PTK/receptor.
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申请公布号 |
US6174674(B1) |
申请公布日期 |
2001.01.16 |
申请号 |
US19980100089 |
申请日期 |
1998.06.19 |
申请人 |
ST. JUDE CHILDREN'S RESEARCH HOSPITAL |
发明人 |
MORRIS STEPHAN W.;LOOK A. THOMAS |
分类号 |
A01K67/027;C07K14/47;C07K14/82;C07K16/18;C07K16/30;C07K19/00;C12N5/00;C12N5/10;C12N9/12;C12N15/09;C12N15/54;C12P21/02;C12Q1/68;C12R1/91;G01N33/50;G01N33/574;(IPC1-7):C12Q1/68;C07H21/02;C07H21/04 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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