发明名称 |
Biomatrix for soft tissue regeneration using mesenchymal stem cells |
摘要 |
An implant for repair of a tissue defect comprises a plurality of physiologically compatible load-bearing sutures for securing under tension tissue adjacent to the defect to be repaired, the sutures for supporting a tissue reparative cell mass in the defect and a tissue reparative cell mass supported thereby. The sutures have a central portion encapsulated in a cell containing matrix which is contracted under a tensile load by the cells thereof and formed into a mat sheet during the contraction. Spring metal wires hold the sutures in tension during the contraction. The matrix is a collagen gel or other material which the cells contract, the cells comprising human mesenchymal stem cells. The mat sheet is then rolled into a spiral roll with the sutures extending from opposite roll ends to form the desired implant. Different embodiments are disclosed.
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申请公布号 |
US6174333(B1) |
申请公布日期 |
2001.01.16 |
申请号 |
US19980222688 |
申请日期 |
1998.12.29 |
申请人 |
OSIRIS THERAPEUTICS, INC.;CASE WESTERN RESERVE UNIVERSITY |
发明人 |
KADIYALA SUDHAKAR;CAPLAN ARNOLD I.;FINK DAVID J.;YOUNG RANDALL G. |
分类号 |
A61B17/00;A61B17/06;A61B17/11;(IPC1-7):A61F2/02 |
主分类号 |
A61B17/00 |
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