| 摘要 |
A phenylsulfonamide derivative of formula (I) <CHEM> (wherein R<1> is H, alkyl; R<2> is COOR<3>, CONHOR<4>; E is vinylene, ethynylene; A is H, alkyl, a carbocyclic ring, a heterocyclic ring; J is a single bond, aklylene; R<9>, R<10> is H, (substituted) alkyl, COR<11>, a carbocyclic ring, a heterocyclic ring etc.; R<20> is H, (substituted) alkyl etc.) and a non-toxic salt thereof, and a process for the preparation thereof, a matrix metalloproteinase inhibitor containing a compound above, and an agent for prevention and/or treatment of rheumatoid diseases, arthrosteitis, unusual bone resorption, osteoporosis, periodontitis, intestitial nephritis, arteriosclerosis, pulmonary emphysema, cirrhosis, cornea injury, metastasis or invasion of tumor cells, a disease induced by proliferation of tumor cells, an autoimmune disease (Crohn's disease or Sjogren's syndrome), diseases caused by vascular emigration and infiltration of leukocytes, or arterialization. |
