发明名称 |
Compositions and methods for treatment of hepatitis C virus-associated diseases |
摘要 |
Antisense oligonucleotides are provided which are complementary to and hybridizable with at least a portion of HCV RNA and which are capable of inhibiting the function of the HCV RNA. These oligonucleotides can be administered to inhibit the activity of Hepatitis C virus in vivo or in vitro. These compounds can be used either prophylactically or therapeutically to reduce the severity of diseases associated with Hepatitis C virus, and for diagnosis and detection of HCV and HCV-associated diseases. Methods of using these compounds are also disclosed.
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申请公布号 |
US6174868(B1) |
申请公布日期 |
2001.01.16 |
申请号 |
US19970988321 |
申请日期 |
1997.12.10 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
ANDERSON KEVIN P.;HANECAK RONNIE C.;NOZAKI CHIKATERU |
分类号 |
C12N15/09;A61K31/711;A61K38/00;A61K38/21;A61K48/00;A61P1/16;A61P31/20;C07H21/04;C07K14/18;C12N15/113;C12Q1/70;(IPC1-7):A61K31/711;A61K31/712 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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